Proteomic Analysis Reveals Selective Impediment of Neuronal Remodeling upon Borna Disease Virus Infection
نویسندگان
چکیده
منابع مشابه
Proteomic analysis reveals selective impediment of neuronal remodeling upon Borna disease virus infection.
The neurotropic virus Borna disease virus (BDV) persists in the central nervous systems of a wide variety of vertebrates and causes behavioral disorders. BDV represents an intriguing example of a virus whose persistence in neurons leads to altered brain function in the absence of overt cytolysis and inflammation. The bases of BDV-induced behavioral impairment remain largely unknown. To better c...
متن کاملThe immunopathogenesis of Borna disease virus infection.
Borna disease virus (BDV) infection represents an excellent model system to study immunopathological mechanisms based on a T cell-mediated immune reaction in the central nervous system. The single-stranded RNA Borna disease virus, a member of Bornaviridae in the order of Mononegavirale, lacks cytopathogenicity both in vitro and in vivo. After experimental infection BDV causes a persistent infec...
متن کاملBorna disease virus infection impairs synaptic plasticity.
The mechanisms whereby Borna disease virus (BDV) can impair neuronal function and lead to neurobehavioral disease are not well understood. To analyze the electrophysiological properties of neurons infected with BDV, we used cultures of neurons grown on multielectrode arrays, allowing a real-time monitoring of the electrical activity across the network shaped by synaptic transmission. Although i...
متن کاملBorna disease virus and infection in humans.
Borna disease virus (BDV) is a nonsegmented, negative-, single-stranded, highly neurotropic RNA virus with noncytolytic replication in the central nervous system. This virus causes neurological and behavioral disturbances primarily in horses and sheep, in addition to a variety of other vertebrate animal species and in laboratory animal models. BDV is now gaining much of the research attention, ...
متن کاملBorna disease virus infection in young children.
Borna Disease Virus infection (BDV) is a well known animal disease. It got its name from a disease outbreak among horses around the small town ‘‘Borna’’, 26 km south-east of Leipzig in the late 19th century. The symptoms in horses have been described in detail and involve neurologic as well as mental and behavioral disorders. A long debate exists whether or not human infections do exist. Severa...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2008
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.01615-08